Preheat the oven to 350°F (175°C). Gather your ingredients to streamline the preparation.

In a large bowl, mix together the ground beef, Italian sausage, breadcrumbs, milk, ketchup, onion, garlic, eggs, Worcestershire sauce, salt, pepper, and parsley until just combined.

Transfer the meat mixture into a loaf pan, evenly shaping it to ensure uniform cooking. Optionally glaze the top with additional ketchup or BBQ sauce.

Bake in the preheated oven for approximately 1 hour or until the internal temperature reaches 160°F (70°C).

Let the meatloaf rest for about 15 minutes before slicing and serving warm.