Preheat your oven to 375°F (190°C). Let store-bought deep-dish crust sit at room temperature for 10 minutes. Press crust into a 9-inch pie pan and pre-bake for 10 minutes.

Heat 2 tablespoons of olive oil in a large skillet over medium heat. Add 1 pound of ground beef and 1 pound of Italian sausage, breaking them apart while cooking. Season with salt, pepper, garlic powder, and Italian seasoning, and cook until browned, about 8-10 minutes. Drain excess grease.

Spread a thin layer of pizza sauce over the pre-baked crust. Sprinkle 1 cup of mozzarella cheese over the sauce, followed by the cooked meat mixture, another layer of sauce, another cup of mozzarella cheese, and arrange pepperoni slices on top. Finish with 1/4 cup of grated Parmesan cheese.

Bake the pie in the oven for 25-30 minutes until cheese is bubbly and golden brown, and the crust is crisp.

Remove the pie from the oven and let it rest for 5-10 minutes before slicing. Garnish with freshly chopped parsley if desired.